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Endothelial adherens junctions and the actin cytoskeleton: an 'infinity net'?

Maria Grazia Lampugnani Journal of Biology 2010, 9:16 (8 April 2010)

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Robust and specific inhibition of microRNAs in Caenorhabditis elegans

Samrat T Kundu, Frank J Slack Journal of Biology 2010, 9:20 (1 April 2010)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Frank Slack and Samrat Kundu highlight a refinement of the antisense strategy used to inhibit miRNAs in C.elegans, published in Silence, with an adaptation that supports transmission through the germline, and combinatorial use to target several different miRNAs in developing tissues.

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Genome of a songbird unveiled

Raphael Pinaud Journal of Biology 2010, 9:19 (1 April 2010)

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Pinaud heralds the publication of the zebra finch genome, reviewing some of the most exciting findings of this pioneering effort and explaining how this songbird model offers unique insights into auditory learning, singing behaviour and other biological phenomena.

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The mathematics of sexual attraction

José A Feijó Journal of Biology 2010, 9:18 (29 March 2010)

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Evolution underground: shedding light on the diversification of subterranean insects

Carlos Juan, Brent C Emerson Journal of Biology 2010, 9:17 (11 March 2010)

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Juan and Emerson discuss the reconstruction of the molecular phylogeny of a large Mediterranean cave-dwelling beetle clade recently presented in BMC Evolutionary Biology, and the implications for the evolutionary origin of the beetle ancestor.

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Scale-eating cichlids: from hand(ed) to mouth

A Richard Palmer Journal of Biology 2010, 9:11 (24 February 2010)

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Palmer discusses recent studies, including one in BMC Biology, suggesting that mouth bending in scale-eating cichlids cannot be explained by frequency dependent selection alone, but that the behavior of the fish may amplify mouth asymmetry during growth.

Opinion   Free Highly Accessed

Top dogs: wolf domestication and wealth

Carlos A Driscoll, David W Macdonald Journal of Biology 2010, 9:10 (24 February 2010)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Commenting on a phylogeographic analysis in BMC Biology that supports a Middle Eastern origin of small dogs, Driscoll and Macdonald speculate on the implications of wolf domestication and size reduction occurring at a time of transition between hunter-gatherer and sedentary societies.

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No better time to FRET: shedding light on host pathogen interactions

Richard D Hayward, Jon D Goguen, John M Leong Journal of Biology 2010, 9:12 (18 February 2010)

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Hayward and colleagues discuss the promise of fluorescence resonance energy transfer (FRET)-based techniques to study the spatio-temporal subversion of host cell signaling by pathogens, reviewing the few existing examples of this, which include a recent paper in BMC Biology, to illustrate the power of an approach that has been surprisingly under-exploited to date.

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Making progress in genetic kin recognition among vertebrates

Jane L Hurst, Robert J Beynon Journal of Biology 2010, 9:13 (17 February 2010)

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Highlighting recent research in BMC Evolutionary Biology that analyzes the scent profiles of ring-tailed lemurs in relation to their genetic distance, Hurst and Benyon discuss recent progress and remaining challenges in deciphering how vertebrates recognise kin by their smell.

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Regeneration review reprise

Jessica L Whited, Clifford J Tabin Journal of Biology 2010, 9:15 (16 February 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Stem cell biology and new high throughput techniques are inspiring new advances in research on regeneration. Whited and Tabin discuss recent developments, including two recent reports in BMC Biology that may mean a reevaluation of the regenerative prospects for humans.

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Acoel and platyhelminth models for stem-cell research

Alexandra E Bely, James M Sikes Journal of Biology 2010, 9:14 (16 February 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

The bodies of platyhelminth and acoel worms are continually renewed from large pools of somatic stem cells. Bely and Sikes discuss their consequent attractiveness for stem cell research, and how recent studies, including one in BMC Developmental Biology, reveal aspects of the cellular dynamics and molecular basis of stem-cell function in these animals.

Research article   Open Access

Madm (Mlf1 adapter molecule) cooperates with Bunched A to promote growth in Drosophila

Silvia Gluderer, Erich Brunner, Markus Germann, Virginija Jovaisaite, Changqing Li, Cyrill A Rentsch, Ernst Hafen, Hugo Stocker Journal of Biology 2010, 9:9 (11 February 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Stocker and colleagues identify and analyze a growth-promoting complex in Drosophila, formed between the putative transcription factor BunA, for which human homologs can functionally substitute, and the adaptor protein Madm.

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Bunched and Madm: a novel growth-regulatory complex?

Kieran F Harvey Journal of Biology 2010, 9:8 (11 February 2010)

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Reviewing how studies in Drosophila have contributed to understanding signaling pathways involved in cancer, Harvey discusses the implications of a Journal of Biology article reporting a BunA/Madm complex that regulates growth in flies.

Question & Answer   Free

Q&A: What can microfluidics do for stem-cell research?

Marie Csete Journal of Biology 2010, 9:1 (11 February 2010)

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Regulation of metabolism in Caenorhabditis elegans longevity

Marco Gallo, Donald L Riddle Journal of Biology 2010, 9:7 (10 February 2010)

Abstract | Full text | PDF | PubMed |  Editor’s summary

A metabolomic quest for universals in the control of lifespan recently reported in BMC Biology implicates branched-chain amino acid pools. Gallo and Riddle review the lessons from C.elegans in research on longevity, and discuss the implications of the metabolomic research.

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Reprogramming of the non-coding transcriptome during brain development

Saba Valadkhan, Timothy W Nilsen Journal of Biology 2010, 9:5 (5 February 2010)

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Valadkhan and Nilsen discuss the mystery of long noncoding RNAs and a recent global expression study in BMC Neuroscience that provides a platform for answering fundamental questions about their role in the development of the brain.

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The THO complex as a key mRNP biogenesis factor in development and cell differentiation

Sonia Jimeno, Andrés Aguilera Journal of Biology 2010, 9:6 (28 January 2010)

Abstract | Full text | PDF | PubMed |  Editor’s summary

The THO complex is implicated in RNA export from the nucleus, but exactly how is not clear. Jimeno and Aguilera discuss a new report on the THOC5 subunit in BMC Biology that suggests a role in differentiation.

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SnoPatrol: how many snoRNA genes are there?

Paul P Gardner, Alex Bateman, Anthony M Poole Journal of Biology 2010, 9:4 (25 January 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Gardner, Bateman and Poole review the current knowledge of small nucleolar RNAs (snoRNAs) and discuss two BMC Genomic papers reporting the identification of novel snoRNAs and the likelihood that there are many more out there.

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Sometimes one just isn't enough: do vertebrates contain an H2A.Z hyper-variant?

Monika Mehta, Hyun-Soo Kim, Michael-Christopher Keogh Journal of Biology 2010, 9:3 (21 January 2010)

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Nucleosomes present a variable platform for recruitment of transcriptional and repair machineries because of variant histones and post-translational modifications. Keogh and colleagues discuss reports in BMC Biology and BMC Evolutionary Biology that suggest further complexity, in conserved variants of the variants.

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Apical polarity in three-dimensional culture systems: where to now?

Jamie L Inman, Mina J Bissell Journal of Biology 2010, 9:2 (21 January 2010)

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The water flea Daphnia - a 'new' model system for ecology and evolution?

Angelika Stollewerk Journal of Biology 2010, 9:21 (13 January 2010)

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Editorial   Open Access Highly Accessed

Top ten in Journal of Biology in 2009: stem cells, influenza, pit bulls, Darwin, and more

Miranda Robertson Journal of Biology 2009, 8:102 (31 December 2009)

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The bacterial pathogen Listeria monocytogenes: an emerging model in prokaryotic transcriptomics

Pascale Cossart, Cristel Archambaud Journal of Biology 2009, 8:107 (30 December 2009)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Cossart and Archambaud discuss the implications of the outcome of deep RNA sequencing used to probe the virulence toolkit of Listeria monocytogenes, reported in a recent paper in BMC Genomics.

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Forward genetics in Tribolium castaneum: opening new avenues of research in arthropod biology

Andrew D Peel Journal of Biology 2009, 8:106 (30 December 2009)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Peel discusses the merits of the flour beetle over the fruit fly as a new arthropod model organism and describes how a new mutagenesis screen published in BMC Biology increases the usefulness of this creature.

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Mapping the protistan 'rare biosphere'

Scott C Dawson, Kari D Hagen Journal of Biology 2009, 8:105 (29 December 2009)

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Dawson and Hagen discuss our current underestimation of the ecological complexity of protist communities in the light of a recent paper in BMC Biology that reports an expanded map of microbial diversity using high throughput sequencing strategy.

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