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The therapeutic potential of modulators of the Hedgehog-Gli signaling pathway

Barbara Stecca and Ariel Ruiz i Altaba*

Author Affiliations

The Skirball Institute, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA

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Journal of Biology 2002, 1:9  doi:10.1186/1475-4924-1-9

Published: 6 November 2002

Abstract

The discovery of small molecules that act as agonists and antagonists of the Hedgehog-Gli signaling pathway, which plays important roles in the embryo and adult, opens a new avenue for the treatment of diseases caused by aberrant suppression or activation of this complex pathway.