Table 1

Examples of diseases caused by loss of or ectopic function of the HH-GLI signaling pathway, and the possible agents that could, in principle, be used as therapeutics

Disease type

Potential therapeutic



Gain-of-function:

Basal cell carcinoma

Antagonist:

Anti-HH antibodies

Medulloblastoma

Forskolin

Rhabdomyosarcoma

Cyclopamine

Cur61414

GLI repressors

Loss-of-function:

Holoprosencephaly

Agonist:

SHH

Hh-Ag*


*Hh-Ag is the Hh agonist described by Frank-Kamenetsky et al.[1].

Stecca and Altaba Journal of Biology 2002 1:9   doi:10.1186/1475-4924-1-9