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Controlling cell division in yeast and animals: does size matter?

Savraj S Grewal* and Bruce A Edgar

Author Affiliations

Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA

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Journal of Biology 2003, 2:5  doi:10.1186/1475-4924-2-5

Published: 24 April 2003

Abstract

In yeast, cell-size checkpoints coordinate cellular growth with cell-cycle progression. Now, evidence has been provided that such checkpoints probably do not exist in mammalian cells. These findings highlight an important difference between how yeast and animal cells proliferate in response to extracellular cues.