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Of mice and men: phylogenetic footprinting aids the discovery of regulatory elements

Zhaolei Zhang and Mark Gerstein*

Author Affiliations

Department of Molecular Biophysics and Biochemistry, Yale University, 266 Whitney Avenue, New Haven, CT 06520-8114, USA

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Journal of Biology 2003, 2:11  doi:10.1186/1475-4924-2-11

Published: 6 June 2003

Abstract

Phylogenetic footprinting is an approach to finding functionally important sequences in the genome that relies on detecting their high degrees of conservation across different species. A new study shows how much it improves the prediction of gene-regulatory elements in the human genome.