Figure 1.

An example of a position-specific weight matrix (PWM) adapted from the TRANSFAC database [5]. The sequences that have been shown experimentally to bind to the human transcription factor GATA-1 have 14 positions, among which only positions 6–10 are fully conserved. Abbreviations: R, G or A (purine); N, any; S, G or C (strong); D, G or A or T. Twelve sequences were used to build this matrix.