Table 1 |
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The reference collection of 14 gene pairs and 40 verified transcription-factor-binding sites used for testing |
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|
Gene name |
Human sequence |
Rodent sequence |
Transcription factors |
Binding sequence |
Location |
MEDLINE ID [49] |
|
|
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|
Skeletal muscle actin |
AF182035* |
M12347 |
SP1 |
GCGGGGTGGCGCG |
-64/-51 |
11017083 |
|
SRF |
ACCCAAATATGGCT |
-100/ -86 |
1922033 |
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|
TEF-1 |
GACATTCCTGCG |
-73/-51 |
11017083 |
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|
Aldolase A α B crystallin |
X12447* |
J05517 |
MEF2 |
CCTAAATATAGGTC |
-125/-111 |
8413246 |
|
M28638* |
U04320 |
SP1 |
AGGAGGAGGGGCA |
-343/-330 |
11017083 |
|
|
SRF |
GCCCAAGATAGTTG |
-393/-379 |
11017083 |
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|
Cardiac α myosin heavy chain |
Z20656 |
U71441 and M62404* |
MEF2 |
TTAAAAATAACTGA |
-327/-313 |
8366095 |
|
TEF-1 |
AGGAGGAATGTGC |
-239/-226 |
7961957 |
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|
SRF |
CTCCAAATTTAGGC |
-62/-48 |
8782063 |
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|
CEBPα |
U34070* |
M62362 |
AP2 α |
GGCCGGGGGCGGA |
-243/-232 |
9520389 |
|
TBP |
TATAAAA |
-30/-24 |
96003748 |
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|
Cell division cycle protein 2 |
L06298 and |
U69555 |
E2F |
TCTTTCGCGC |
-131/-119 |
94094909 |
|
X66172* |
cETS |
GGGAAG |
-109/-104 |
951721551 |
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|
Cholesterol 7 α hydroxylase |
L13460 |
U01962* |
HNF3 β |
TCTGTTTGTTCT |
-175/-166 |
9799805 |
|
cEBP |
ATGTTATGTCA |
-227/-217 |
28182075 |
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|
Early growth response protein 1 |
AJ243425 |
M22326* |
SRF |
TGCTTCCCATATATGGCCATGT |
-88/-67 |
90097904 |
|
SRF |
CCAGCGCCTTATATGGAGTGGC |
-358/-337 |
90097904 |
|||
|
SRF |
GAAACGCCATATAAGGAGCAGG |
-412/-391 |
90097904 |
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|
Glucose-6-phosphatase |
AF051355* |
U57552 |
HNF3 β |
CCAAAGA |
-72/-66 |
9369482 |
|
HNF3 β |
ACAAACG |
-91/-85 |
9369482 |
|||
|
HNF3 β |
GTTTTTGAG |
-82/-74 |
9369482 |
|||
|
HNF3 β |
TGTGTGC |
-180/-174 |
9369482 |
|||
|
HNF3 β |
TGTTTGC |
-139/-133 |
9369482 |
|||
|
HNF1 |
AGTTAATCATTGGCC |
-226/-212 |
9369482 |
|||
|
Leptin |
U43589 |
U36238* |
SP1 |
GGGCGG |
-100/-95 |
9492033 |
|
cEBP |
GTTGCGCAAG |
-58/-49 |
9492033 |
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|
TBP |
TATAAG |
-33/-28 |
9492033 |
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|
Lipoprotein lipase |
M29549* |
M63335 |
NFY |
CAAT |
-65/-61 |
1918010 |
|
cEBP |
TAGCCAAT |
-68/-61 |
1918010 |
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|
TBP |
TATAA |
-27/-23 |
1918010 |
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|
Muscle creatine kinase |
M21487 |
AF188002 and M21390* |
SRF |
CCATGTAAGG |
-1236/-1227 |
93233638 |
|
AP2 α |
GGCCTGGGGA |
-1220/-1211 |
93233638 |
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|
MEF2 |
TCTAAAAATAAC |
-1078/-1067 |
93233638 |
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|
MYF |
GGGCCAGCTGTCCC |
-253/-240 |
96347575 |
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|
MYF |
CCAACACCTGCTGC |
-1157/-1144 |
96347575 |
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|
P53 |
ATACAAGGCC |
-176/-167 |
96047120 |
|||
|
P53 |
ATACAAGGCC |
-158/-149 |
96047120 |
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|
Rb susceptibility gene |
L11910* |
M86180 U49920 and S66110 |
SP1 |
GGGCGG |
-202/-188 |
1881452 |
|
Troponin I |
L21905* |
MEF2 |
AGACTATAATAGCC |
-976/-962 |
9774679 |
|
|
MYF |
TAAACAGGTGCAGC |
-879/-865 |
9774679 |
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|
|
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|
GenBank accession numbers [41] are given for the human and rodent sequences. The transcription-factor-binding sequences refer to the human or rodent sequence(s) marked with an asterisk. 'Location' refers to the position of the TFBS relative to the transcription start site. |
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|
Lenhard et al. Journal of Biology 2003 2:13 doi:10.1186/1475-4924-2-13 |
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