Shrinkage control: regulation of insulin-mediated growth by FOXO transcription factors
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Journal of Biology 2003, 2:18 doi:10.1186/1475-4924-2-18Published: 11 September 2003
The insulin signaling pathway regulates organismal growth in response to nutrient conditions by controlling a range of metabolic and biosynthetic processes. Recent studies in Drosophila have shown how transcriptional responses to reduced insulin and nutrient levels can act to inhibit growth.