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At the crossroads: AMP-activated kinase and the LKB1 tumor suppressor link cell proliferation to metabolic regulation

John M Kyriakis

Author Affiliations

Molecular Cardiology Research Institute, Tufts-New England Medical Center, 750 Washington Street, Boston, MA 02111, USA

Journal of Biology 2003, 2:26  doi:10.1186/1475-4924-2-26

Published: 22 October 2003

Abstract

The tumor suppressor kinase LKB1 has been identified as a physiologic activator of the key metabolic regulator 5'-AMP-activated protein kinase, establishing a possible molecular link between the regulation of metabolism and cell proliferation.