|
Selected genes up- or down-regulated in transgenic lungs |
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| Affymetrix probe ID |
Allele |
Gene name |
GenBank accession numbers |
Fold change (transgenic/ wild-type) |
p value |
|
|
|
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| Genes down-regulated in transgenic lungs |
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| Specialized cell markers |
||||||
| 1418818_at |
Aqp5 |
aquaporin 5 |
Mm.45580 |
NM_009701 |
96.1 |
0.009 |
| 1449015_at |
Retnla |
resistin like alpha |
Mm.33772 |
NM_020509 |
37.5 |
0.004 |
| 1436996_x_at |
Lyzs |
lysozyme |
Mm.45436 |
AV066625 |
36.5 |
6.82E-04 |
| 1451537_at |
Chi3l1 |
chitinase 3-like 1 |
Mm.4376 |
BC005611 |
30.5 |
0.002 |
| 1429626_at |
Sftpa |
surfactant associated protein A |
Mm.46062 |
AV024301 |
30.1 |
0.004 |
| 1420504_at |
Slc6a14 |
solute carrier family 6 (neurotransmitter transporter)14 |
Mm.25770 |
AF320226 |
21.4 |
0.023 |
| 1419020_at |
Gif |
gastric intrinsic factor |
Mm.456 |
NM_008118 |
19.7 |
0.003 |
| 1416456_a_at |
Chia |
chitinase, acidic |
Mm.46418 |
BC011134 |
16.0 |
0.012 |
| 1423547_at |
Lyzs |
lysozyme |
Mm.45436 |
AW208566 |
14.8 |
0.004 |
| 1419764_at |
Chi3l3 |
chitinase 3-like 3 |
Mm.4571 |
NM_009892 |
13.6 |
0.013 |
| 1420378_at |
Sftpd |
surfactant associated protein D |
Mm.1321 |
BC003705 |
12.0 |
2.10E-04 |
| 1448553_at |
Myh7 |
myosin, heavy polypeptide 7, cardiac muscle, beta |
Mm.155714 |
NM_080728 |
11.7 |
0.011 |
| 1455431_at |
Slc5a1 |
solute carrier family 5 (sodium/glucose cotransporter)1 |
Mm.25237 |
AV371434 |
10.4 |
0.025 |
| 1437028_at |
Sftpb |
surfactant associated protein B |
Mm.46033 |
AV025094 |
9.8 |
5.41E-04 |
| 1438696_at |
Edn3 |
endothelin 3 |
Mm.9478 |
BB368452 |
7.0 |
0.016 |
| 1452543_a_at |
Scgb1a1 |
secretoglobin, family 1A, member 1 (uteroglobin) |
Mm.2258 |
X67702 |
5.2 |
0.014 |
| 1425291_at |
Foxj1 |
forkhead box J1 |
Mm.4985 |
L13204 |
2.3 |
0.006 |
| Genes up-regulated in transgenic lungs |
||||||
| Cell proliferation markers |
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| 1451417_at |
Brca1 |
breast cancer 1 |
Mm.1889 |
U31625 |
9.5 |
0.004 |
| 1416969_at |
Gtse1 |
G two S phase expressed protein 1 |
Mm.20858 |
NM_013882 |
5.9 |
7.58E-04 |
| 1416122_at |
Ccnd2 |
cyclin D2 |
Mm.3141 |
NM_009829 |
3.5 |
1.27E-04 |
| 1422460_at |
Mad2l1 |
MAD2 (mitotic arrest deficient, homolog)-like 1 (yeast) |
Mm.43444 |
NM_019499 |
3.2 |
0.014 |
| 1425166_at |
Rbl1 |
retinoblastoma-like 1 (p107) |
Mm.2994 |
U27178 |
3.1 |
0.007 |
| 1417420_at |
Ccnd1 |
cyclin D1 |
Mm.22288 |
BB538325 |
2.2 |
0.002 |
| Transcription factors and Notch/Delta signaling |
||||||
| 1421299_a_at |
Lef1 |
lymphoid enhancer binding factor 1 |
Mm.200634 |
NM_010703 |
58.7 |
1.29E-04 |
| 1426552_a_at |
Bcl11a |
B-cell CLL/lymphoma 11A (zinc finger protein) |
Mm.24020 |
BB772866 |
19.5 |
0.001 |
| 1417679_at |
Gfi1 |
growth factor independent 1 |
Mm.2078 |
NM_010278 |
18.0 |
0.038 |
| 1449236_at |
Dll3 |
delta-like 3 (Drosophila) |
Mm.12896 |
AB013440 |
16.7 |
0.001 |
| 1424903_at |
Smcy |
selected mouse cDNA on the Y |
Mm.1064 |
AF127244 |
10.8 |
0.006 |
| 1451835_at |
Sox21 |
SRY-box containing gene 21 |
Mm.70950 |
AY069926 |
8.9 |
0.001 |
| 1449822_at |
Atoh1 |
atonal homolog 1 (Drosophila) |
Mm.57229 |
BC010820 |
7.4 |
0.001 |
| 1422914_at |
Sp5 |
transacting transcription factor 5 |
Mm.155690 |
NM_022435 |
7.1 |
0.043 |
| 1448595_a_at |
Rex3 |
reduced expression 3 |
Mm.14768 |
NM_009052 |
6.5 |
2.55E-04 |
| 1450164_at |
Ascl1 |
achaete-scute complex homolog-like 1 (Drosophila) |
Mm.10663 |
NM_008553 |
6.1 |
0.007 |
| 1460336_at |
Ppargc1 |
peroxisome proliferative activated receptor, gamma, coactivator 1 |
Mm.10707 |
BB745167 |
5.7 |
0.039 |
| 1418055_at |
Neurod4 |
neurogenic differentiation 4 |
Mm.10695 |
NM_007501 |
5.2 |
0.017 |
| 1424950_at |
Sox9 |
SRY-box containing gene 9 |
Mm.46607 |
BI077717 |
5.1 |
0.019 |
| 1450339_a_at |
Bcl11b |
B-cell lymphoma/leukaemia 11B |
Mm.116831 |
NM_021399 |
5.0 |
0.042 |
| 1460214_at |
Pcp4 |
Purkinje cell protein 4 |
Mm.5023 |
NM_008791 |
4.5 |
0.012 |
| 1415811_at |
Np95 |
nuclear protein 95 |
Mm.42196 |
BB702754 |
4.0 |
0.037 |
| 1419437_at |
Sim2 |
single-minded 2 |
Mm.4775 |
NM_011377 |
3.9 |
0.03 |
| 1415810_at |
Np95 |
nuclear protein 95 |
Mm.42196 |
NM_010931 |
3.9 |
0.017 |
| 1451255_at |
Lisch7 |
liver-specific bHLH-Zip transcription factor |
Mm.4067 |
BC004672 |
3.7 |
8.53E-04 |
| 1421951_at |
Lhx1 |
LIM homeobox protein 1 |
Mm.4965 |
NM_008498 |
3.3 |
0.014 |
| 1417302_at |
Rcor |
RE1-silencing transcription factor (REST) co-repressor |
Mm.22980 |
NM_054048 |
3.3 |
0.047 |
| 1422088_at |
Lmyc1 |
Mus musculus, clone IMAGE:1528432, mRNA |
Mm.198846 |
BI687857 |
3.0 |
0.001 |
| 1424942_a_at |
Myc |
myelocytomatosis oncogene |
Mm.2444 |
BC006728 |
2.6 |
7.85E-04 |
| 1417155_at |
Nmyc1 |
neuroblastoma myc-related oncogene 1 |
Mm.16469 |
BC005453 |
2.3 |
0.01 |
| Specialized cell markers |
||||||
| Paneth cells |
||||||
| 1450709_at |
Defcr5 |
defensin related cryptdin 5 |
Mm.140173 |
NM_007851 |
844.0 |
0.003 |
| 1416905_at |
Guca2 |
guanylate cyclase activator 2 (guanylin 2, intestinal, heatstable) |
Mm.2614 |
NM_008190 |
322.2 |
0.001 |
| 1450631_x_at |
Defcr6 |
defensin related cryptdin 6 |
Mm.246485 |
NM_007852 |
187.6 |
0.002 |
| 1427119_at |
Spink4 |
serine protease inhibitor, Kazal type 4 |
Mm.25246 |
AV066321 |
99.5 |
1.18E-04 |
| 1418550_x_at |
Defcr-rs1 |
defensin related sequence cryptdin peptide (paneth cells) |
Mm.14269 |
NM_007844 |
22.8 |
0.007 |
| 1449478_at |
Mmp7 |
matrix metalloproteinase 7 |
Mm.4825 |
NM_010810 |
9.0 |
0.002 |
| 1434852_at |
Pla2g2e |
phospholipase A2, group IIE |
Mm.89936 |
AV228827 |
8.0 |
0.049 |
| 1427873_at |
Defcr15 |
defensin related cryptdin 15 |
Mm.195047 |
U03065 |
3.4 |
0.019 |
| 1419254_at |
Mthfd2 |
methylenetetrahydrofolate dehydrogenase (NAD+ dependent) |
Mm.443 |
BG076333 |
2.6 |
0.004 |
| Other cells |
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| 1417459_at |
Dcpp |
demilune cell and parotid protein |
Mm.193062 |
NM_019910 |
285.6 |
8.59E-05 |
| 1450618_a_at |
Sprr2a |
small proline-rich protein 2A |
Mm.6853 |
NM_011468 |
34.2 |
2.39E-04 |
| 1449279_at |
Gpx2 |
glutathione peroxidase 2 |
Mm.57225 |
NM_030677 |
18.6 |
1.83E-04 |
| 1418931_at |
Reg4 |
regenerating islet-derived family member 4 |
Mm.46306 |
NM_026328 |
15.4 |
0.001 |
| 1417370_at |
Tff3 |
trefoil factor 3, intestinal |
Mm.4641 |
NM_011575 |
12.0 |
0.001 |
| 1419127_at |
Npy |
neuropeptide Y |
Mm.154796 |
NM_023456 |
7.2 |
0.033 |
| 1427355_at |
Calca |
calcitonin/calcitonin-related polypeptide, alpha |
Mm.4361 |
X97991 |
5.0 |
0.019 |
| 1420965_a_at |
Enc1 |
ectodermal-neural cortex 1 |
Mm.241073 |
BM120053 |
4.1 |
6.25E-04 |
| 1448290_at |
Pap |
pancreatitis-associated protein |
Mm.2553 |
NM_011036 |
2.6 |
0.022 |
| 1417281_a_at |
Mmp23 |
matrix metalloproteinase 23 |
Mm.29373 |
NM_011985 |
2.4 |
0.045 |
| 1422597_at |
Mmp15 |
matrix metalloproteinase 15 |
Mm.7283 |
NM_008609 |
2.4 |
0.003 |
| 1421195_at |
Cckar |
cholecystokinin A receptor |
Mm.3521 |
BC020534 |
2.1 |
0.004 |
| Extracellular signaling factors |
||||||
| 1416211_a_at |
Ptn |
pleiotrophin |
Mm.3063 |
BF178348 |
25.5 |
7.50E-05 |
| 1454159_a_at |
Igfbp2 |
insulin-like growth factor binding protein 2 |
Mm.141936 |
AK011784 |
24.9 |
0.007 |
| 1422324_a_at |
Pthlh |
parathyroid hormone-like peptide |
Mm.28440 |
NM_008970 |
22.8 |
0.001 |
| 1422300_at |
Nog |
noggin |
Mm.39094 |
NM_008711 |
12.8 |
9.64E-04 |
| 1423635_at |
Bmp2 |
Bmp2 |
Mm.29877 |
AV239587 |
9.3 |
0.019 |
| 1448254_at |
Ptn |
pleiotrophin |
Mm.3063 |
BC002064 |
7.9 |
7.62E-04 |
| 1418910_at |
Bmp7 |
bone morphogenetic protein 7 |
Mm.595 |
NM_007557 |
6.2 |
0.004 |
| 1450922_a_at |
Tgfb2 |
transforming growth factor, beta 2 |
Mm.18213 |
AW049938 |
4.5 |
1.06E-04 |
| 1420518_a_at |
Igsf9 |
immunoglobulin superfamily, member 9 |
Mm.214530 |
AF317839 |
4.4 |
0.007 |
| 1450923_at |
Tgfb2 |
transforming growth factor, beta 2 |
Mm.18213 |
BF144658 |
4.3 |
7.04E-04 |
| 1416006_at |
Mdk |
midkine |
Mm.906 |
M34328 |
4.1 |
4.19E-04 |
|
For details of the Affymetrix GeneChip mouse 430A array analysis, which used RNA from three transgenic and three wild-type E18.5 lungs, see Materials and methods. Only selected genes taken from categories discussed in the text are shown. For the complete set of genes up- or down-regulated more than two-fold, and for the raw data, see Additional data files 2, 3 and 4. | ||||||
Okubo and Hogan Journal of Biology 2004 3:11 doi:10.1186/jbiol3 |
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