Email updates

Keep up to date with the latest news and content from Journal of Biology and BioMed Central.

Research news

The curious world of apoptotic cell clearance

Jonathan B Weitzman

Journal of Biology 2004, 3:13  doi:10.1186/jbiol13

PubMed Commons is an experimental system of commenting on PubMed abstracts, introduced in October 2013. Comments are displayed on the abstract page, but during the initial closed pilot, only registered users can read or post comments. Any researcher who is listed as an author of an article indexed by PubMed is entitled to participate in the pilot. If you would like to participate and need an invitation, please email info@biomedcentral.com, giving the PubMed ID of an article on which you are an author. For more information, see the PubMed Commons FAQ.

Phosphatidylserine receptor (PSR) is required for the engulfment of dead apoptotic cells and for normal embryonic development in zebrafish

Ding Xue   (2004-10-15 20:13)  University of Colorado

A paper was published in Development online (Development. 2004 Oct 6 [Epub ahead of print]), reporting that the PSR knockdown by a PSR morpholino oligonucleotide led to accumulation of a large number of dead apoptotic cells in whole early embryo. These unengulfed cells interfere with embryonic cell migration. In addition, normal development of the somite, brain, heart, and notochord was sequentially disrupted up to 24 hours post-fertilization. The phenotypes of the PSR knockdown in Zebrafish are quite similar to the PSR knockout phenotypes reported by Li et al. in Science. Thus in three organisms examined so far (worm, zebrafish, and mice) PSR is important for removal of apoptotic cell corpses. I think that this paper will help resolve the current controversial regarding PSR.

Competing interests

None declared

top

Post a comment