Hide and seek: the secret identity of the phosphatidylserine receptor
1 Department of Biology, Amherst College, Amherst, MA 01002, USA
2 Department of Biochemistry and Molecular Biology, Penn State University, University Park, PA 16802, USA
Journal of Biology 2004, 3:14 doi:10.1186/jbiol14
Published: 23 September 2004Abstract
Phosphatidylserine on the dying cell surface helps identify apoptotic cells to phagocytes, which then engulf them. A candidate phagocyte receptor for phosphatidylserine was identified using phage display, but the phenotypes of knockout mice lacking this presumptive receptor, as well as the location of the protein within cells, cast doubt on the assignment of this protein as the phosphatidylserine receptor.
