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Open AccessHighly AccessResearch article

The functional landscape of mouse gene expression

Wen Zhang* 1,2 email, Quaid D Morris* 1,3 email, Richard Chang1, Ofer Shai3, Malina A Bakowski1, Nicholas Mitsakakis1, Naveed Mohammad1, Mark D Robinson1, Ralph Zirngibl2, Eszter Somogyi2, Nancy Laurin2, Eftekhar Eftekharpour4, Eric Sat5, Jörg Grigull1, Qun Pan1, Wen-Tao Peng1, Nevan Krogan1,2, Jack Greenblatt1,2, Michael Fehlings4,6, Derek van der Kooy2, Jane Aubin2, Benoit G Bruneau2,7, Janet Rossant2,5, Benjamin J Blencowe1,2, Brendan J Frey3 and Timothy R Hughes1,2 email

1Banting and Best Department of Medical Research, University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8, Canada

2Department of Medical Genetics and Microbiology, University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8, Canada

3Department of Electrical and Computer Engineering, University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8, Canada

4Department of Surgery, University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8, Canada

5Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, ON M5G 1X5, Canada

6Division of Cell and Molecular Biology, Toronto Western Research Institute and Krembil Neuroscience Center, 399 Bathurst St., Toronto, ON M5T 2S8, Canada

7The Hospital for Sick Children, 555 University Ave., Toronto, ON M5G 1X8, Canada

author email corresponding author email* Contributed equally

Journal of Biology 2004, 3:21doi:10.1186/jbiol16

Published: 6 December 2004

Additional files

Additional data file 1:

XM (predicted mRNA sequences) from NCBI

Format: FA Size: 53.7MB Download file

Additional data file 2:

XP (encoded protein sequences) from NCBI

Format: FA Size: 12.5MB Download file

Additional data file 3:

Array Design 1 (spot map)

Format: TDT Size: 2.1MB Download file

Additional data file 4:

Array Design 2 (spot map)

Format: TDT Size: 2.1MB Download file

Additional data file 5:

Array Master file - 41,699 probes; the Master file contains probe sequences, columns listing the closest sequences in RIKEN, ENSEMBL, Refseq, and Unigene; GenBank description, EST overlap, GO-BP annotations, Domain (most significant)

Format: XLS Size: 20.5MB Download file

This file can be viewed with: Microsoft Excel Viewer

Additional data file 6:

Array information after removal of redundant probes: probe combinations

Format: TXT Size: 89KB Download file

Additional data file 7:

Array information after removal of redundant probes: master file - 39,309 presumed distinct transcripts

Format: XLS Size: 21.2MB Download file

This file can be viewed with: Microsoft Excel Viewer

Additional data file 8:

Hybridization records

Format: XLS Size: 29KB Download file

This file can be viewed with: Microsoft Excel Viewer

Additional data file 9:

Figure 1 data

Format: XLS Size: 101KB Download file

This file can be viewed with: Microsoft Excel Viewer

Additional data file 10:

Figure 2b data

Format: XLS Size: 29KB Download file

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Additional data file 11:

Figure 4a data

Format: ZIP Size: 2.6MB Download file

Additional data file 12:

Figure 4b data

Format: ZIP Size: 2.6MB Download file

Additional data file 13:

Figure 4c data

Format: ZIP Size: 245KB Download file

Additional data file 14:

Figure 4d data

Format: TXT Size: 27KB Download file

Additional data file 15:

Figure 5 data

Format: XLS Size: 993KB Download file

This file can be viewed with: Microsoft Excel Viewer

Additional data file 16:

Figure 7 data

Format: TXT Size: 516KB Download file

Additional data file 17:

Supplementary figures S1-3

Format: PDF Size: 55KB Download file

This file can be viewed with: Adobe Acrobat Reader

Additional data file 18:

Data: 41,699 probes - single channel, arcsinh intensities

Format: ZIP Size: 17.2MB Download file

Additional data file 19:

Data: 41,699 probes - replicates combined, arcsinh intensities

Format: ZIP Size: 9.2MB Download file

Additional data file 20:

Data: 41,699 probes - median-subtracted, zeroed

Format: ZIP Size: 5.4MB Download file

Additional data file 21:

Data: 39,309 presumed distinct transcripts - median-subtracted, zeroed

Format: ZIP Size: 5.1MB Download file

Additional data file 22:

Data: 21,622 presumed distinct transcripts - median-subtracted and zeroed, expressed above 99% of negative-control spots

Format: ZIP Size: 2.8MB Download file

Additional data file 23:

Data: binary matrix of expression above 99% of negative-control spots

Format: ZIP Size: 319KB Download file

Additional data file 24:

Annotations: GO annotations among 39,309 presumed distinct transcripts (12,543 annotated genes, 47,900 annotations)

Format: ZIP Size: 202KB Download file

Additional data file 25:

Annotations: GO annotations among 21,622 presumed distinct transcripts (9,499 annotated genes, 37,876 annotations)

Format: ZIP Size: 162KB Download file

Additional data file 26:

Annotations: superGO annotations

Format: ZIP Size: 88KB Download file

Additional data file 27:

Annotations: map between GO and superGO annotations

Format: XLS Size: 73KB Download file

This file can be viewed with: Microsoft Excel Viewer

Additional data file 28:

SVM Predictions: GO-BP SVM Predictions, 15% precision

Format: XLS Size: 5.5MB Download file

This file can be viewed with: Microsoft Excel Viewer

Additional data file 29:

SVM Predictions: GO-BP SVM Predictions, 50% precision

Format: XLS Size: 529KB Download file

This file can be viewed with: Microsoft Excel Viewer

Additional data file 30:

SVM Predictions: superGO SVM Predictions, 15% precision

Format: XLS Size: 3.7MB Download file

This file can be viewed with: Microsoft Excel Viewer

Additional data file 31:

SVM Predictions: superGO SVM Predictions, 50% precision

Format: XLS Size: 273KB Download file

This file can be viewed with: Microsoft Excel Viewer

Additional data file 32:

RT-PCR primer sequences

Format: XLS Size: 28KB Download file

This file can be viewed with: Microsoft Excel Viewer

Additional data file 33:

XM genes with gene trap lines

Format: XLS Size: 1MB Download file

This file can be viewed with: Microsoft Excel Viewer

Additional data file 34:

XM motifs

Format: XLS Size: 4.4MB Download file

This file can be viewed with: Microsoft Excel Viewer

Additional data file 35:

779 known and putative DNA-binding transcription factors among XM genes

Format: XLS Size: 137KB Download file

This file can be viewed with: Microsoft Excel Viewer

Additional data file 36:

Table of accession numbers of genes common to Zhang, Su, and Bono data

Format: TXT Size: 36KB Download file

Additional data file 37:

Tech report on spatial detrending

Format: PDF Size: 2.2MB Download file

This file can be viewed with: Adobe Acrobat Reader

Additional data file 38:

Map locations of XM genes (BLASTed against Build 32) - retained only if top hit of both XM sequence and array probe overlap (30,387 presumed distinct transcripts)

Format: XLS Size: 4.5MB Download file

This file can be viewed with: Microsoft Excel Viewer

Additional data file 39:

SVM functional predictions for 7,147 unannotated mapped transcripts (may be useful for positional cloning), also see [19]

Format: XLS Size: 7.7MB Download file

This file can be viewed with: Microsoft Excel Viewer

Additional data file 40:

175 lists of genes that are expressed in individual tissues, highest in individual tissues, or specific to individual tissues

Format: TXT Size: 7.7MB Download file


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