Table 1

Domains associated with genes predicted to function in specific biological processes

Predicted function

Enriched domain

Description of domain

Proportion of genes with this domain

-log₁₀ significance (P)

Chromosome organization or DNA packaging

HMG

HMG (high mobility group) box

13/87

10.5

Pregnancy/embryo implantation

Hormone_1

Somatotropin hormone family

3/14

7.3

Acyl-CoA/fatty acid/peroxisome

FabG

Short-chain alcohol dehydrogenase

3/11

6.8

RNA/ribosome metabolism/processing

RRM

RNA recognition motif

10/149

6.6

Carboxylic acid/amine metabolism

ECH

Enoyl-CoA hydratase/isomerase family

3/62

6.2

Humoral immune response

Sp100

The function of this domain is unknown

2/95

6.1

Vision

Uteroglobin

The function of this domain is unknown

3/56

5.9

RNA-nucleus import/export

COG5136

U1 snRNP-specific protein C

2/13

5.7

Microtubule-based process

Smc

Chromosome-segregation ATPases

4/86

5.2

P values were calculated using the hypergeometric P value [48], which compares against expectation from random draws among the 15,443 XM genes with encoded domains. Domain names and descriptions are from the NCBI 'COG' database [65].

Zhang et al. Journal of Biology 2004 3:21   doi:10.1186/jbiol16