Wnt signals via canonical and non-canonical pathways. Both start when Wnt ligand binds the Frizzled receptor at the cell surface, and both include the key mediator Dsh. Dsh is made up of three major motifs plus nuclear import (NLS) and export signals (NES); the red arrow indicates the newly identified direct route Dsh takes into the nucleus. The roles of the other proteins in the two pathways, and of the Dsh motifs, are discussed in the text.
Weitzman Journal of Biology 2005 4:1 doi:10.1186/jbiol21