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Dishevelled and Wnt signaling: is the nucleus the final frontier?

Raymond Habas1 and Igor B Dawid2*

Author affiliations

1 Cancer Institute of New Jersey and Department of Biochemistry, UMDNJ-Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA

2 Laboratory of Molecular Genetics, National Institutes of Child Health and Human Development, Bethesda, MD 20892-2790, USA

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Citation and License

Journal of Biology 2005, 4:2  doi:10.1186/jbiol22

Published: 17 February 2005

Abstract

The phosphoprotein Dishevelled (Dsh) is an essential component of Wnt signaling pathways and transduces signals into three separate branches, the canonical, non-canonical and Ca2+ pathways. How Dsh focuses signaling into these branches remains mysterious, but a new study reveals the importance of nuclear localization of Dsh for pathway-specific activation.