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The GTPase switch in ribosomal translocation

Pete Moore

Author Affiliations

Journal of Biology 2005, 4:7  doi:10.1186/jbiol28

Published: 27 June 2005

Abstract

Information from careful measurements of the affinity of ribosome-associated proteins for GTP and GDP, and from structural analyses, suggests that elongation factor-G must assume three different structures during protein synthesis and that the ribosome itself acts as a guanine-nucleotide exchange factor. Is it time to re-write the textbook description of translation?