A balancing act between the X chromosome and the autosomes
Departments of Pathology and Medicine, University of Washington, Seattle, WA 98195, USA
Journal of Biology 2006, 5:2 doi:10.1186/jbiol32Published: 16 February 2006
Dosage compensation equalizes gene dosage between males and females, but its role in balancing expression between the X chromosome and the autosomes may be far more important. Now, DNA microarrays have shown equality between the average expression of X-linked genes and that of autosomal genes, in male and female tissues of flies, worms and mice.