Global analysis of X-chromosome dosage compensation

doi:10.1186/jbiol30

Journal of Biology

Volume 5
Issue 1

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Gupta V
Parisi M
Sturgill D
Nuttall R
Doctolero M
Dudko OK
Malley JD
Eastman PS
Oliver B

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Gupta V
Parisi M
Sturgill D
Nuttall R
Doctolero M
Dudko OK
Malley JD
Eastman PS
Oliver B
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Research article

Global analysis of X-chromosome dosage compensation

Vaijayanti Gupta¹ , Michael Parisi¹ , David Sturgill¹ , Rachel Nuttall²^,4 , Michael Doctolero²^,4 , Olga K Dudko³ , James D Malley³ , P Scott Eastman²^,4 and Brian Oliver¹

¹Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 50 South Drive, Bethesda, MD 20892, USA

²Incyte Genomics, Palo Alto, CA 94304, USA

³Mathematical and Statistical Computing Laboratory, Division of Computational Bioscience, Center for Information Technology, National Institutes of Health, Bethesda, MD 20982, USA

⁴Current address: Quantum Dot Corporation, Hayward, CA 94545, USA

author email corresponding author email

Journal of Biology 2006, 5:3doi:10.1186/jbiol30


Published:	16 February 2006

Additional files

Additional data file 1:

A figure showing the effect of different data handling techniques on differential expression resulting from altered gene dose on the autosomes

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Additional data file 2:

A figure showing the experimental design in detail

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Additional data file 3:

One-way ANOVA comparisons

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Additional data file 4:

Estimation of Hodges-Lehmann (HL) median differences between expression ratios in various experiments

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Additional data file 5:

Estimation of Hodges-Lehmann (HL) median differences between signal intensities in various experiments

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Additional data file 6:

A figure showing a simple picture depicting bootstrap HL estimates of median differences followed by the Kolmogorov-Smirnov (KS) test

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