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Malaria pigment paralyzes dendritic cells

Britta C Urban email and Stephen Todryk

Centre for Clinical Vaccinology and Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Churchill Hospital, Old Road, Oxford, OX3 7LJ, UK

author email corresponding author email

Journal of Biology 2006, 5:4doi:10.1186/jbiol37

Published: 12 April 2006

Abstract

The capacity of malarial infection to suppress the patient's immune responses both to the parasite and to other antigens has long puzzled researchers. A prime suspect, the parasite-produced pigment hemozoin, has now been clearly shown to mediate immunosuppression by inhibiting dendritic cell activity.


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