Malaria pigment paralyzes dendritic cells
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Journal of Biology 2006, 5:4 doi:10.1186/jbiol37Published: 12 April 2006
The capacity of malarial infection to suppress the patient's immune responses both to the parasite and to other antigens has long puzzled researchers. A prime suspect, the parasite-produced pigment hemozoin, has now been clearly shown to mediate immunosuppression by inhibiting dendritic cell activity.