Open Access Highly Accessed Research article

Comprehensive curation and analysis of global interaction networks in Saccharomyces cerevisiae

Teresa Reguly1, Ashton Breitkreutz1, Lorrie Boucher12, Bobby-Joe Breitkreutz1, Gary C Hon3, Chad L Myers45, Ainslie Parsons26, Helena Friesen6, Rose Oughtred4, Amy Tong26, Chris Stark1, Yuen Ho6, David Botstein4, Brenda Andrews26, Charles Boone26, Olga G Troyanskya45, Trey Ideker3, Kara Dolinski4, Nizar N Batada1 and Mike Tyers12*

Author Affiliations

1 Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto ON M5G 1X5, Canada

2 Department of Medical Genetics and Microbiology, University of Toronto, Toronto ON M5S 1A8, Canada

3 Department of Bioengineering, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0412, USA

4 Lewis-Sigler Institute for Integrative Genomics, Princeton University, Washington Road, Princeton, NJ 08544, USA

5 Department of Computer Science, Princeton University, NJ 08544, USA

6 Banting and Best Department of Medical Research, University of Toronto, Toronto ON M5G 1L6, Canada

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Journal of Biology 2006, 5:11  doi:10.1186/jbiol36

Published: 8 June 2006

Additional files

Additional data file 1:

Supplementary Table 1, LC and HTP dataset statistics; Supplementary Table 2, Co-purified complexes in the LC dataset; Supplementary Table 3, SI/HTP publications; Supplementary Table 4, Post-translational modifications associated with interactions; Supplementary Table 5, Overlap of physical and genetic interaction datasets; Supplementary Table 6, Predicted yeast complexes from yeast interaction datasets; Supplementary Table 7, Predicted yeast complexes from yeast and fly interaction datasets; Supplementary Table 8, Novel human predicted human protein interactions; Supplementary Table 9, Novel GO functional predictions for yeast proteins; Supplementary Table 10, Novel GO functional predictions for fly proteins; Supplementary Table 11, Publications documented in the HTP-GI dataset

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Additional data file 2:

A comparison of the LC dataset with other curated datasets and details of functional predictions

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Additional data file 3:

Supplementary Figure 1, Curation benchmarks for the LC dataset; Supplementary Figure 2, Distribution of terms in GO categories in LC-PI and LC-GI dataset; Supplementary Figure 3, Relative coverage and overlap of interaction datasets; Supplementary Figure 4, Raw distributions of interactions for each indicated dataset as a function of protein abundance; Supplementary Figure 5, Expression correlation for interaction pairs in LC versus HTP datasets; Supplementary Figure 6, Dense regions in the physical interaction network

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Additional data file 4:

Flat files of the main datasets

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