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Regulators of kinesin involved in polarized trafficking and axon outgrowth

Shuo Luo and Michael L Nonet*

Author Affiliations

Department of Anatomy and Neurobiology, Washington University School of Medicine, 660 S. Euclid Avenue, Saint Louis, MO 63110, USA

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Journal of Biology 2006, 5:8  doi:10.1186/jbiol41

Published: 25 May 2006

Abstract

Proteins such as UNC-76 that associate with kinesin motors are important in directing neurite extension. A small Caenorhabditis elegans coiled-coil protein, UNC-69, has now been shown to interact with UNC-76 and to be involved in axonal (but not dendritic) transport and outgrowth, as well as synapse formation.