Open Access Highly Accessed Research article

The short coiled-coil domain-containing protein UNC-69 cooperates with UNC-76 to regulate axonal outgrowth and normal presynaptic organization in Caenorhabditis elegans

Cheng-Wen Su12, Suzanne Tharin1034, Yishi Jin5, Bruce Wightman6, Mona Spector4, David Meili1117, Nancy Tsung128, Christa Rhiner12, Dimitris Bourikas27, Esther Stoeckli27, Gian Garriga9, H Robert Horvitz8 and Michael O Hengartner12*

Author Affiliations

1 Institute for Molecular Biology, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland

2 Neuroscience Center Zurich, ETH and University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland

3 Program in Genetics, SUNY at Stony Brook, Stony Brook, NY 11794, USA

4 Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA

5 Howard Hughes Medical Institute, Department of Molecular, Cellular and Developmental Biology, Sinsheimer Laboratories, University of California, Santa Cruz, CA 95064, USA

6 Biology Department, Muhlenberg College, Allentown, PA 18104, USA

7 Zoological Institute, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland

8 Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA

9 Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA

10 Current address: Department of Neurosurgery, Brigham and Women's Hospital, Children's Hospital and Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA

11 Current address: Abteilung für Klinische Chemie und Biochemie, Universitäts-Kinderklinik, Steinwiesstrasse 75, CH-8032 Zürich, Switzerland

12 Current address: Clinigen, Inc., 400 W. Cummings Park #5700, Woburn, MA 01801, USA

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Journal of Biology 2006, 5:9  doi:10.1186/jbiol39

Published: 25 May 2006

Additional files

Additional data file 1:

Supplementary results and tables

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Additional data file 2:

A figure showing that the overexpression of a full-length UNC-69(M1I)::GFP protein rescues locomotion defects of the unc-69(e587) mutants

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Additional data file 3:

A figure showing the extent of the ok339 deletion

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Additional data file 4:

A figure showing that RNAi knockdown of chicken UNC-69/SCOCO results in epaxial nerve pathfinding defects

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