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Highly Accessed Comment

Dimerization in protein kinase signaling

Steven Pelech

Author Affiliations

The Brain Research Centre, Division of Neurology, 2211 Wesbrook Mall, University of British Columbia, Vancouver, BC V6T 2B5, Canada

Journal of Biology 2006, 5:12  doi:10.1186/jbiol45

Published: 19 July 2006

Abstract

The closely related mitogen-activated protein kinases ERK1 and ERK2 have now been shown to have opposing roles in Ras-mediated cell proliferation. I propose that dimerization of these highly related protein kinases could underlie these surprising observations and that this could be a common paradigm for widespread regulation of protein phosphorylation by kinase-substrate interactions.