Dimerization in protein kinase signaling
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Journal of Biology 2006, 5:12 doi:10.1186/jbiol45Published: 19 July 2006
The closely related mitogen-activated protein kinases ERK1 and ERK2 have now been shown to have opposing roles in Ras-mediated cell proliferation. I propose that dimerization of these highly related protein kinases could underlie these surprising observations and that this could be a common paradigm for widespread regulation of protein phosphorylation by kinase-substrate interactions.