Journal of Biology


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Distinct functions for ERKs?

Alison C Lloyd

Journal of Biology 2006, 5:13 doi:10.1186/jbiol46

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ERK1 and ERK2 MAPK are key regulators of distinct gene sets in zebrafish embryogenesis

SF Gabby Krens, Maximiliano Corredor-Adámez, Shuning He, B Ewa Snaar-Jagalska, Herman P Spaink BMC Genomics 2008, 9:196 (28 April 2008)

The signalling proteins ERK1 and ERK2 target distinct sets of genes and play key roles during zebrafish embryogenesis, ERK1 in dorso-ventral patterning and cell migration, and ERK2 in cell migration, mesoderm differentiation and patterning.

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The small molecule Mek1/2 inhibitor U0126 disrupts the chordamesoderm to notochord transition in zebrafish

Thomas A Hawkins, Florencia Cavodeassi, Ferenc Erdélyi, Gábor Szabó, Zsolt Lele BMC Developmental Biology 2008, 8:42 (17 April 2008)