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Distinct functions for ERKs?

Alison C Lloyd

Author Affiliations

MRC Laboratory for Molecular Cell Biology and Department of Biochemistry, University College London, Gower Street, London WC1E 6BT, UK

Journal of Biology 2006, 5:13  doi:10.1186/jbiol46

Published: 19 July 2006

Abstract

The Ras/Raf/MEK/ERK signaling pathway is one of the best understood signal routes in cells. Recent studies add complexity to this cascade by indicating that the two ERK kinases, ERK1 (p44ERK1) and ERK2 (p42ERK2), may have distinct functions.