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Volume 5 (2006) - June 2006

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Research article   Open Access Highly Accessed

ERK1 and ERK2 mitogen-activated protein kinases affect Ras-dependent cell signaling differentially

Chiara Vantaggiato, Ivan Formentini, Attilio Bondanza, Chiara Bonini, Luigi Naldini, Riccardo Brambilla Journal of Biology 2006, 5:14 (28 June 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

The mitogen-activated protein kinases ERK1 and ERK2 have unexpectedly independent roles in normal and malignant Ras-dependent cell proliferation; ERK2 controls normal cell proliferation whereas ERK1 antagonizes ERK2 activity.

Research article   Open Access Highly Accessed

Comprehensive curation and analysis of global interaction networks in Saccharomyces cerevisiae

Teresa Reguly, Ashton Breitkreutz, Lorrie Boucher, Bobby-Joe Breitkreutz, Gary C Hon, Chad L Myers, Ainslie Parsons, Helena Friesen, Rose Oughtred, Amy Tong, Chris Stark, Yuen Ho, David Botstein, Brenda Andrews, Charles Boone, Olga G Troyanskya, Trey Ideker, Kara Dolinski, Nizar N Batada, Mike Tyers Journal of Biology 2006, 5:11 (8 June 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

A new literature-based yeast database documents over 33,000 biological interactions, manually curated from the primary literature, and provides an invaluable resource to benchmark high-throughput methods in the study of complex networks.

Minireview   Free Highly Accessed

The interaction map of yeast: terra incognita?

Joe Mellor, Charles DeLisi Journal of Biology 2006, 5:10 (8 June 2006)

Abstract | Full text | PDF | PubMed


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