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Does gene dosage really matter?

Jennifer A Marshall Graves1* and Christine M Disteche2

Author Affiliations

1 Research School of Biological Sciences, Australian National University, Canberra, ACT 2601, Australia

2 Departments of Pathology and Medicine, University of Washington, Seattle, WA 98195, USA

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Journal of Biology 2007, 6:1  doi:10.1186/jbiol55

Published: 22 March 2007

Abstract

Mechanisms to compensate for dosage differences of genes on sex chromosomes are widespread in animals and have been thought to be critical for viability. However, in birds, compensation is inefficient, implying that for many genes dosage compensation is not critical, and for some genes, dosage differences have even been selected for.