Research article
Dosage compensation is less effective in birds than in mammals
-
* Corresponding author: Arthur P Arnold arnold@ucla.edu
- † Equal contributors
Journal of Biology 2007, 6:2 doi:10.1186/jbiol53
Gene dosage - its misunderstood basis
Denys Wheatley (2007-04-05 14:52) Editor in Chief, CCI and TBMM
Dr Itoh et al's paper, while interesting in its specific detail, has not grasped the basis of gene dosage. I recommend the authors reconsider this basis by consulting two early papers in TBMM (Theoretical Biology and Medical Modelling), which is a BMC journal. The references are to John W Porteous' papers:
TBMM 1, 4, 2004
TBMM 1, 6, 2004
both of which are discussion on the meaning of Mendelian "genetics" (traits) when considered in the light of Kacser's Metabolic Regulation Hypothesis. Gene dosage is best understood only when levels of enzymes (or their products) approach a rate-limiting level within any metabolic (biocheical) pathway.
Competing interests
As indicated above, I am foundin editor (Editor-in Chief) of BMC's CCI and TBMM journals
top