Yuichiro Itoh, Esther Melamed, Xia Yang, Kathy Kampf, Susanna Wang, Nadir Yehya, Atila Van Nas, Kirstin Replogle, Mark R Band, David F Clayton, Eric E Schadt, Aldons J Lusis and Arthur P Arnold*
Corresponding author: Arthur P Arnold firstname.lastname@example.org
Journal of Biology 2007, 6:2 doi:10.1186/jbiol53
(2007-04-05 14:52) Editor in Chief, CCI and TBMM
Dr Itoh et al's paper, while interesting in its specific detail, has not grasped the
basis of gene dosage. I recommend the authors reconsider this basis by consulting
two early papers in TBMM (Theoretical Biology and Medical Modelling), which is a BMC
journal. The references are to John W Porteous' papers:
TBMM 1, 4, 2004
TBMM 1, 6, 2004
both of which are discussion on the meaning of Mendelian "genetics" (traits) when
considered in the light of Kacser's Metabolic Regulation Hypothesis. Gene dosage is
best understood only when levels of enzymes (or their products) approach a rate-limiting
level within any metabolic (biocheical) pathway.
As indicated above, I am foundin editor (Editor-in Chief) of BMC's CCI and TBMM journals
BioMed Central Ltd unless otherwise stated. Part of Springer Science+Business Media.