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Multilevel regulation of growth rate in yeast revealed using systems biology

Arvind Ramanathan and Stuart L Schreiber*

Author Affiliations

The Broad Institute of Harvard & MIT, Chemical Biology Program, 7 Cambridge Center, Cambridge, MA 02142, USA

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Journal of Biology 2007, 6:3  doi:10.1186/jbiol56

Published: 30 April 2007

Abstract

The effect of changing growth rates on the transcriptome, proteome and metabolome has been systematically studied. Measurements made under varying nutrient conditions, corresponding to biochemical pathways that correlate primarily with growth rate, reveal a central role for mitochondrial metabolism and the TOR (target of rapamycin) signaling pathway.