A schematic diagram showing the approaches used to investigate whether synthetic genetic network connectivity is conserved. In all panels, nodes represent genes and lines represent interactions. (a) Among pairs of homologous genes tested for interaction in both worm and yeast, we investigated whether there was significant overlap between worm (pink) and yeast (blue) genetic interactions (left), or few overlapping interactions (right). (b) After identifying subnetworks (groups of highly interconnected nodes linked by green, purple or light-blue links) within the superimposed network, we investigated whether worm (pink) and yeast (blue) genetic interactions link the same (left) or different (right) subnetworks.
Byrne et al. Journal of Biology 2007 6:8 doi:10.1186/jbiol58