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A summary of the query genes |
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| Query gene |
Ortholog (pathway) |
Null/strong loss-of-function phenotype(s) |
Hypomorphic phenotype(s) |
References |
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|
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| let-756 |
FGF (FGF) |
Early larval arrest (s2887) |
scrawny, Slo (s2613)** |
[77] |
| egl-15 |
FGF receptor (FGF) |
Early larval arrest (n1456) |
scrawny, Egl (n1477)** |
[78] |
| let-23 |
EGF receptor (EGF) |
L1 arrest (mn23) |
ts Vul, pleotropic (n1045)** |
[79] |
| daf-2 |
Insulin growth factor receptor (insulin) |
Emb (e979) |
ts Daf-c (e1370)** |
[35] |
| sem-5 |
GRB-2 (EGF, FGF, insulin) |
L1 arrest (leaky) (n1619) |
Egl, Vul (n2019)* |
[79,80] |
| sos-1 |
Guanine-nucleotide exchange factor (EGF, FGF) |
Emb (s1031) |
ts Egl, Vul (cs41)* |
[33] |
| let-60 |
RAS (EGF, FGF, insulin, Wingless/Wnt) |
Mid-larval lethal (leaky) (s1124) |
Egl, Vul (n2021)* |
[81,82] |
| glp-1 |
Notch receptor (Notch) |
ts Emb (gp60) |
ts Emb, Glp, Muv (or178)* |
[47] |
| bar-1 |
β-catenin (Wingless (Wnt)) |
Mig, Vul, Pvl (ga80)** |
Mig, Vul, Pvl (mu63) |
[34] |
| sma-6 |
Type I TGF-β receptor (TGF-β) |
Sma, Mab (wk7) |
Sma (e1482)* |
[83] |
| clk-2 |
Tel-2p (DNA-damage response) |
Unknown |
Slo, Ste, ts Emb (mn159)** |
[84] |
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In the second column, 'ortholog' refers to the canonical ortholog in yeast, flies, mice, or humans. The pathway to which the ortholog belongs is in brackets. Third column: if known, the null or strong loss-of-function phenotype is shown. Fourth column: weak loss-of-function (hypomorphic) phenotypes are shown for representative alleles. Phenotypic acronyms: Emb, embryonic lethal; Daf-c, dauer formation constitutive; Slo, slow growth; Egl, egg-laying defective; Vul, vulvaless; Glp, germ-line proliferation defects; Muv, multivulva; Mig, cell and/or axon migration defects; Pvl, protruding vulva; Sma, small body; Mab, male tail abnormal; Ste, sterile; ts, temperature sensitive. The alleles used in this study are followed by two asterisks if used as a query against both the signaling targets and the LGIII targets, or just a single asterisk if used only against the signaling targets. | ||||
Byrne et al. Journal of Biology 2007 6:8 doi:10.1186/jbiol58 |
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