Table 1

A summary of the query genes

Query gene

Ortholog (pathway)

Null/strong loss-of-function phenotype(s)

Hypomorphic phenotype(s)

References

let-756

FGF (FGF)

Early larval arrest (s2887)

scrawny, Slo (s2613)**

[77]

egl-15

FGF receptor (FGF)

Early larval arrest (n1456)

scrawny, Egl (n1477)**

[78]

let-23

EGF receptor (EGF)

L1 arrest (mn23)

ts Vul, pleotropic (n1045)**

[79]

daf-2

Insulin growth factor receptor (insulin)

Emb (e979)

ts Daf-c (e1370)**

[35]

sem-5

GRB-2 (EGF, FGF, insulin)

L1 arrest (leaky) (n1619)

Egl, Vul (n2019)*

[79,80]

sos-1

Guanine-nucleotide exchange factor (EGF, FGF)

Emb (s1031)

ts Egl, Vul (cs41)*

[33]

let-60

RAS (EGF, FGF, insulin, Wingless/Wnt)

Mid-larval lethal (leaky) (s1124)

Egl, Vul (n2021)*

[81,82]

glp-1

Notch receptor (Notch)

ts Emb (gp60)

ts Emb, Glp, Muv (or178)*

[47]

bar-1

β-catenin (Wingless (Wnt))

Mig, Vul, Pvl (ga80)**

Mig, Vul, Pvl (mu63)

[34]

sma-6

Type I TGF-β receptor (TGF-β)

Sma, Mab (wk7)

Sma (e1482)*

[83]

clk-2

Tel-2p (DNA-damage response)

Unknown

Slo, Ste, ts Emb (mn159)**

[84]

In the second column, 'ortholog' refers to the canonical ortholog in yeast, flies, mice, or humans. The pathway to which the ortholog belongs is in brackets. Third column: if known, the null or strong loss-of-function phenotype is shown. Fourth column: weak loss-of-function (hypomorphic) phenotypes are shown for representative alleles. Phenotypic acronyms: Emb, embryonic lethal; Daf-c, dauer formation constitutive; Slo, slow growth; Egl, egg-laying defective; Vul, vulvaless; Glp, germ-line proliferation defects; Muv, multivulva; Mig, cell and/or axon migration defects; Pvl, protruding vulva; Sma, small body; Mab, male tail abnormal; Ste, sterile; ts, temperature sensitive. The alleles used in this study are followed by two asterisks if used as a query against both the signaling targets and the LGIII targets, or just a single asterisk if used only against the signaling targets.

Byrne et al. Journal of Biology 2007 6:8   doi:10.1186/jbiol58