A simplified diagram of the link between glycolysis and the pentose phosphate pathway. The pentose phosphate pathway is linked to glycolysis through glucose 6-phosphate; if it is oxidized, it enters the pentose phosphate pathway, whereas if it is isomerized to fructose-6-phosphate, it continues through glycolysis. Inhibiting glycolysis through alterations in the activity of TPI or GAPDH redirects the metabolic flux towards the pentose phosphate pathway and generation of NADPH. Abbreviations: 6PG, 6-phosphogluconate; 6PGDH, 6-phosphogluconate dehydrogenase; DHAP, dihydroxyacetone phosphate; G6PDH, glucose 6-phosphate dehydrogenase; GAPDH, glyceraldehyde 3-phosphate dehydrogenase; P, phosphate; R5P, ribulose 5-phosphate; TPI, triosephosphate isomerase.
Grant Journal of Biology 2008 7:1 doi:10.1186/jbiol63