Minireview
A bridge to transcription by RNA polymerase
Author affiliations
Department of Structural Biology, Stanford University, 299 Campus Dr. West, Stanford, CA 94305, USA
Citation and License
Journal of Biology 2008, 7:39 doi:10.1186/jbiol99
Published: 2 December 2008Abstract
A comprehensive survey of single amino-acid substitution mutations critical for RNA polymerase function published in Journal of Biology supports a proposed mechanism for polymerase action in which movement of the polymerase 'bridge helix' promotes transcriptional activity in cooperation with a critical substrate-interaction domain, the 'trigger loop'.
