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Open Access Research article

Bridge helix and trigger loop perturbations generate superactive RNA polymerases

Lin Tan, Simone Wiesler, Dominika Trzaska, Hannah C Carney and Robert OJ Weinzierl*

Author Affiliations

Department of Life Sciences, Imperial College London, Sir Alexander Fleming Building, Exhibition Road, London SW7 2AZ, UK

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Journal of Biology 2008, 7:40  doi:10.1186/jbiol98

Published: 2 December 2008

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Structure, evolution and function of mjA' L814.

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Structure, evolution and function of mjA' R830.

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Additional file 18:

Chromatographic elution profiles of wild-type and mutant mjRNAPs.

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Additional file 19:

Activities of wild-type and mutant mjRNAPs at limiting and saturating template DNA concentrations.

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Additional file 20:

Functional consequences of proline substitutions in different bridge helix positions.

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Additional file 21:

Bioinformatic analysis of intrinsic folding properties of bridge helices and trigger loops.

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