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Semaphorins deployed to repel cell migrants at spinal cord borders

Sophie Chauvet and Geneviève Rougon*

Author Affiliations

CNRS UMR 6216, Université de la Méditerranée, Developmental Biology Institute of Marseille Luminy, Case 907 Parc Scientifique de Luminy, 13288 Marseille cedex 09, France

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Journal of Biology 2008, 7:4 doi:10.1186/jbiol65

Published: 7 February 2008

Abstract

In the spinal cord, developing motor neurons extend their axons into the periphery while their cell bodies remain within the motor columns in the spinal cord. Two recent papers show that this partitioning involves forward and reverse semaphorin-plexin signaling between motor neurons and neural crest boundary cap cells.