Semaphorins deployed to repel cell migrants at spinal cord borders
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Journal of Biology 2008, 7:4 doi:10.1186/jbiol65Published: 7 February 2008
In the spinal cord, developing motor neurons extend their axons into the periphery while their cell bodies remain within the motor columns in the spinal cord. Two recent papers show that this partitioning involves forward and reverse semaphorin-plexin signaling between motor neurons and neural crest boundary cap cells.