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Great exaptations

Kathleen H Burns1 and Jef D Boeke2 email

1Department of Pathology, The Johns Hopkins Hospital, 600 North Wolfe Street, Baltimore, MD 21287, USA

2High Throughput Biology Center, Johns Hopkins University School of Medicine, 733 North Broadway, Baltimore, MD 21205, USA

author email corresponding author email

Journal of Biology 2008, 7:5doi:10.1186/jbiol66

Published: 15 February 2008

Abstract

Long interspersed nuclear elements (LINEs) are among the most successful parasitic genetic sequences in higher organisms. Recent work has discovered many instances of LINE incorporation into exons, reminding us of the hazards they pose to genes in their vicinity as well as their potential to be co-opted for the host's purposes.


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