Functions of O-fucosyltransferase in Notch trafficking and signaling: towards the end of a controversy?

doi:10.1186/jbiol68

Journal of Biology

Volume 7
Issue 2

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Functions of O-fucosyltransferase in Notch trafficking and signaling: towards the end of a controversy?

Nicolas Vodovar¹^,2 and François Schweisguth¹^,2

¹Ecole Normale Supérieure, CNRS UMR8542, 46 rue d'Ulm, 75005 Paris, France.

²Institut Pasteur, CNRS URA2578, 25 rue du Dr Roux, 75015 Paris, France.

Journal of Biology 2008, 7:7doi:10.1186/jbiol68


Published:	28 February 2008

Abstract

The precise role of the O-fucosyltransferase Ofut1 in Notch-receptor trafficking has remained controversial. A recent study sheds new light on the non-catalytic activity of Ofut1 and provides further evidence that Ofut1 acts as a chaperone in the endoplasmic reticulum.