Minireview Functions of O-fucosyltransferase in Notch trafficking and signaling: towards the end of a controversy?Nicolas Vodovar1,2 and François Schweisguth1,2 1Ecole Normale Supérieure, CNRS UMR8542, 46 rue d'Ulm, 75005 Paris, France. 2Institut Pasteur, CNRS URA2578, 25 rue du Dr Roux, 75015 Paris, France.
Journal of Biology 2008, 7:7doi:10.1186/jbiol68
AbstractThe precise role of the O-fucosyltransferase Ofut1 in Notch-receptor trafficking has remained controversial. A recent study sheds new light on the non-catalytic activity of Ofut1 and provides further evidence that Ofut1 acts as a chaperone in the endoplasmic reticulum. |
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