Functions of O-fucosyltransferase in Notch trafficking and signaling: towards the end of a controversy?
1 Ecole Normale Supérieure, CNRS UMR8542, 46 rue d'Ulm, 75005 Paris, France.
2 Institut Pasteur, CNRS URA2578, 25 rue du Dr Roux, 75015 Paris, France.
Journal of Biology 2008, 7:7 doi:10.1186/jbiol68Published: 28 February 2008
The precise role of the O-fucosyltransferase Ofut1 in Notch-receptor trafficking has remained controversial. A recent study sheds new light on the non-catalytic activity of Ofut1 and provides further evidence that Ofut1 acts as a chaperone in the endoplasmic reticulum.