Imp-L2, a putative homolog of vertebrate IGF-binding protein 7, counteracts insulin signaling in Drosophila and is essential for starvation resistance

Basil Honegger¹ , Milos Galic¹^,3 , Katja Köhler² , Franz Wittwer¹ , Walter Brogiolo¹ , Ernst Hafen² and Hugo Stocker²

¹Zoological Institute, University of Zürich, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland

²Institute for Molecular Systems Biology (IMSB), ETH Zürich, Wolfgang-Pauli-Strasse 16, CH-8093 Zürich, Switzerland

³Current address: Chemical and Systems Biology, 318 Campus Drive, Clark Building W200, Stanford University Medical Center, Stanford, CA 94305-5174, USA

author email corresponding author email

Journal of Biology 2008, 7:10doi:10.1186/jbiol72


Published:	15 April 2008

Additional files

Additional data file 1:

Figure S1 shows that the over-expression of Imp-L2 results in reduced PIP₃levels in vivo. In Figure S2, the dynamic expression pattern of Imp-L2 during development is shown. Figure S3 demonstrates that a reduction in Dilp levels enhances the growth-inhibitory effect of Imp-L2.

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