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A Caenorhabditis elegans genetic-interaction map wiggles into view

Kristin C Gunsalus

Author affiliations

Center for Genomics and Systems Biology and Department of Biology, New York University, 1009 Silver Center, 100 Washington Square East, New York, NY 10003, USA

Citation and License

Journal of Biology 2008, 7:8  doi:10.1186/jbiol70

Published: 7 March 2008

Abstract

Systematic mapping of genetic-interaction networks will provide an essential foundation for understanding complex genetic disorders, mechanisms of genetic buffering and principles of robustness and evolvability. A recent study of signaling pathways in Caenorhabditis elegans lays the next row of bricks in this foundation.