Systemic 5-fluorouracil treatment causes a syndrome of delayed myelin destruction in the central nervous system

Ruolan Han¹ , Yin M Yang¹ , Joerg Dietrich² , Anne Luebke³ , Margot Mayer-Pröschel¹ and Mark Noble¹

¹Department of Biomedical Genetics and University of Rochester Stem Cell and Regenerative Medicine Institute, University of Rochester Medical Center, Elmwood Avenue, Rochester, NY 14642, USA

²Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Fruit Street, Wang 835, Boston, MA 02114, USA

³Department of Neurobiology and Anatomy, University of Rochester Medical Center, Elmwood Avenue, Rochester, NY 14642, USA