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Evolution of virulence in malaria

Bridget Penman and Sunetra Gupta*

Author Affiliations

Department of Zoology, University of Oxford, South Parks Road, Oxford, OX1 3PS, UK

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Journal of Biology 2008, 7:22  doi:10.1186/jbiol83

Published: 28 August 2008

Abstract

The pathogenesis of severe malarial disease is not yet fully understood. It is clear that host immunopathology plays a central role, and a recent paper in BMC Evolutionary Biology suggests that the ability of the parasite to stimulate interleukin-10 production is a major factor and speculates on its impact on the coevolution of host and parasite.