Evolution of virulence in malaria
Department of Zoology, University of Oxford, South Parks Road, Oxford, OX1 3PS, UK
Journal of Biology 2008, 7:22 doi:10.1186/jbiol83Published: 28 August 2008
The pathogenesis of severe malarial disease is not yet fully understood. It is clear that host immunopathology plays a central role, and a recent paper in BMC Evolutionary Biology suggests that the ability of the parasite to stimulate interleukin-10 production is a major factor and speculates on its impact on the coevolution of host and parasite.