Figure 4.

GDAs^CNTF express GFAP and neurocan after transplantation into spinal cord injuries. (a) Intra-injury GDAs^CNTF are uniformly GFAP⁺ within acute dorsal column injuries. Note the co-localization (yellow) of human placental alkaline phosphatase (hPAP, red) with GFAP (green). GDAs^CNTF have also failed to align host astrocytic processes within injury margins. Survival, 8 days post-injury/transplantation. (b) High-magnification confocal image of neurocan immunoreactivity at the injury margin and within a GDA^CNTF-transplanted injury site at 8 days after injury/transplantation. Note that some GDAs^CNTF are immunoreactive for neurocan (green). In contrast, intra-injury transplanted GDAs^BMP (not shown) do not express GFAP or neurocan, and can align host astrocytic processes within injury margins [14]. Scale bars 100 μm.