Table 1

Summary of GDAs^BMP, GDAs^CNTF and GRPs effects on spinal cord injury repair and allodynia

Effect

GDAs^BMP

GDAs^CNTF

GRPs

Promote axon growth across spinal cord injury

+++

-

-

Promote locomotor recovery

+++

-

-

Suppress atrophy of injured red nucleus neurons

+++

-

-

Induce mechanical and thermal allodynia

-

+++

+++

Promote sprouting of CGRP⁺ axons in lamina III

-

+++

+++

Align host astrocytes at injury site

+++

-

-

Transiently suppress host CSPG expression

+++

+++

+++

Express inhibitory CSPGs within injury site

-

+++

+++

Express CSPGs in vitro

+

+++

+++

Davies et al. Journal of Biology 2008 7:24   doi:10.1186/jbiol85