NFIX – one gene, two knockouts, multiple effects

doi:10.1186/jbiol94

Journal of Biology

Volume 7
Issue 8

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NFIX – one gene, two knockouts, multiple effects

Vladimir Pekarik¹ and Juan Carlos Izpisua Belmonte¹^,2

¹Center of Regenerative Medicine in Barcelona, Doctor Aiguader 88, 08003 Barcelona, Spain

²Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA

author email corresponding author email

Journal of Biology 2008, 7:29doi:10.1186/jbiol94


Published:	23 October 2008

Abstract

A previous knockout of the transcription factor gene nuclear factor IX (NFIX) in mice produced impaired development of the corpus callosum and severe skeletal defects. A recent paper in BMC Developmental Biology reports an apparently similar NFIX knockout that produced marked differences in phenotype, raising intriguing general questions about the possible causes of such differences in mouse knockouts.